2 separate listeners on 2 logical IPv4 and 2 IPv6 addresses configured on separate physical interfaces
segregates incoming and outgoing traffic
you can assign an IPv4 and an IPv6 address to each listener
Segregating Incoming and Outgoing Mail
You can segregate incoming and outgoing email traffic over separate listeners and on separate IP addresses. You can use Internet Protocol version 4 (IPv4) and version 6 (IPv6) addresses. However, the System Setup Wizard on the email gateway supports initial configuration of the following configurations:
2 separate listeners on 2 logical IPv4 and 2 IPv6 addresses configured on separate physical interfaces
segregates incoming and outgoing traffic
you can assign an IPv4 and an IPv6 address to each listener
1 listener on 1 logical IPv4 address configured on one physical interface
combines both incoming and outgoing traffic
you can assign both an IPv4 and an IPv6 address to the listener
https://www.cisco.com/c/en/us/td/docs/security/esa/esa14-0/user_guide/b_ESA_Admin_Guide_14-0/b_ESA_Admin_Guide_12_1_chapter_010.html
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