With static NAT enabled on LAN2 of the Expressway-E, the c-line of the SIP INVITE has now been rewritten to c=IN IP4 64.100.0.10, and this means that when endpoint B sends outbound RTP media to endpoint A, this will be sent to IP address 64.100.0.10, the public NAT address of the NAT router, which is 1:1 NATed to the LAN2 IP address of the Expressway-E, 10.0.10.2. As RTP media from endpoint B arrives at the NAT router with a destination IP address of 64.100.0.10, the NAT router will forward these packets to the Expressway-E at 10.0.10.2 and two-way media is achieved.
https://www.cisco.com/c/dam/en/us/td/docs/voice_ip_comm/expressway/config_guide/X8-5/Cisco-Expressway-Basic-Configuration-Deployment-Guide-X8-5-2.pdf
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