C is correct answer
The following are the prerequisites to integrate Active Directory with Cisco ISE. + Use the
Network Time Protocol (NTP) server settings to synchronize the time between the Cisco ISE
server and Active Directory. You can configure NTP settings from Cisco ISE CLI. + If your Active
Directory structure has multidomain forest or is divided into multiple forests, ensure that
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trust relationships exist between the domain to which Cisco ISE is connected and the other
domains that have user and machine information to which you need access. For more information
on establishing trust relationships, refer to Microsoft Active Directory documentation. + You must
have at least one global catalog server operational and accessible by Cisco ISE, in the domain to
which you are joining Cisco ISE.
Reference: https://www.cisco.com/c/en/us/td/docs/security/ise/2-
0/ise_active_directory_integration/b_ISE_AD_integration_2x.html#reference_8DC463597A644A5
C9CF5D582B77BB24F
Answer is C. Otherwise you may get Kerberos Auth errors due to clock skew
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