I think layer 2 would still function, but there could be layer 3 issues: If you do not follow this best practice, keep in mind that if a VDS spans more than one host cluster and the transport zone includes only one (or a subset) of these clusters, any logical switch included within this transport zone can access VMs within all clusters spanned by the VDS. In other words, the transport zone will not be able to constrain the logical switch span to a subset of the clusters. If this logical switch is later connected to a DLR, you must ensure that the router instances are created only in the cluster included in the transport zone to avoid any Layer 3 issues.
--> "If a cluster requires Layer 3 connectivity, the cluster must be in a transport zone that also contains an edge cluster, meaning a cluster that has Layer 3 edge devices (distributed logical routers and edge services gateways)."
https://docs.vmware.com/en/VMware-NSX-Data-Center-for-vSphere/6.2/com.vmware.nsx.admin.doc/GUID-5EFF202E-42DE-4864-9B60-C5FF280457F6.html
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